Sheldon just resigned from his job and ran away. Now, Howard and Raj are anxious about his disappearance. Leonard, though, tends to have other plans than searching for Sheldon.
(Season 3, Episode 1: The Electric Can Opener Fluctuation)
Howard: Red alert, Leonard. Sheldon ran away.
Leonard: Man, I cannot catch a break.
Penny: So, how do you know he ran away?
Howard: Well, he’s not answering his phone, he handed in his resignation at the university and he sent me a text that said, I’m running away.
Leonard: Okay, well, thanks for letting me know.
Penny: Well, Leonard, aren’t you going to do something?
Leonard: Of course I’m going to do something. Uh, Howard, you check the comic book store. Raj, go to the Thai restaurant. I’ll stay here with Penny in her apartment. Oh, damn it. It’s Sheldon’s mother. A break cannot be caught. Hi, Mrs. Cooper. He is? Sheldon went home to Texas. Yeah, no, I know he resigned. Yes, I guess it kind of is our fault. No, no, no, you, you’re right, someone needs to come talk to him. Don’t worry, I’ll take care of it. Yeah. All right. New plan. Howard, you and Raj go to Texas. I’ll stay here with Penny in her apartment.
red alert = a sudden dangerous situation you have to deal with
to catch a break = to have some luck or a lucky opportunity
resignation = the act of telling your employer that you are leaving your job
damn it (also: dammit or damnit) = an expression of anger (informal)
to resign = If you resign from a job or position, you formally announce that you are leaving it.
(definitions taken from the Cambridge and Collins Dictionary)
Other funny scenes from Big Bang Theory:
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